FEMALE INFERTILITY HAS MANY FACTORS

Infertility means being unable to get pregnant after at least one year of trying (or six months if the woman is over age 35). Infertility results from female factors about one-third of the time and male factors about one-third of the time. If a woman keeps having miscarriages, this is also called infertility. Female infertility contributes to nearly 50 percent of all infertility cases.

….FULL ARTICLE

UNDERSTANDING DEPRESSION IN WOMEN

Depression is a common but serious mood disorder. It reveals itself through symptoms such as hopelessness, pessimism, irritability, guilt, helplessness and decreased energy or fatigue lasting at least two weeks or longer. About twice as many women as men experience depression. Several factors may increase a woman’s risk of depression.

….FULL ARTICLE

RECOVERING FROM A HEART ATTACK

What happens now?  That is a question you could ask after surviving a heart attack.  How do you take care of yourself afterwards so that there is no repeat?  According to Family Doctor (www.familydoctor.org), a heart attack happens when part of the heart muscle is damaged or dies because it does not receive enough oxygen. The blood in the coronary arteries carries oxygen to the heart muscle. Most heart attacks occur when a blockage slows down or stops the flow of blood through these arteries.

….FULL ARTICLE

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Better understanding of the type of depression a person experiences couldi mprove the effectiveness of treatment choices and the management of depressive symptoms. Depression is typically diagnosed based on verbalized symptoms patients experience. This relates to the way the symptoms are assessed and the accuracy of patient reporting.


Conor Liston, M.D., a professor of neuroscience and psychiatry at Weill Cornell Medicine in New York, reports his research team, using brain scans, has identified four unique subtypes of clinical depression based on distinct patterns of abnormal brain connectivity. Their findings appear currently in Nature Medicine (December 2016).


“The four subtypes of depression that we discovered vary in terms of their clinical symptoms but, more importantly, they differ in their responses to treatment,” said Liston. For psychiatric care and treatment, using brain scans may assist mental health professionals in understanding the nature of a patient’s depression.


This collaborative study included 1,180 functional magnetic resonance imaging (fMRI) brain scans of patients with clinical depression and healthy controls from across the country. Researchers from Weill Cornell Medicine and seven other institutions analyzed the scans and identified biomarkers linked with depression by assigning statistical weights

CURRENT RESEARCH REVEALS FOUR DEPRESSION SUBTYPES

to abnormal brain connections. They then predicted the probability the abnormal connections belonged to a particular subtype versus another. The study showed distinct patterns of abnormal connectivity in the brain differentiated among the four subtypes and were linked with specific symptoms. Reduced connectivity in the brain region that regulates fear-related behavior and reappraisal of negative emotional stimuli, for example, was most severe in two of the four subtypes, which demonstrated increased anxiety. The researchers believe their findings may be useful for identifying patients most likely to benefit from targeted neuro-stimulation therapies. In the past, efforts to characterize depression by looking at groups of verbalized symptoms that tend to co-occur and then testing neurophysiological links have produced inconsistent results.


Sources and Resources:


•  Drysdale, A.T., Grosenick, L., Downar, J., et al. (2016) Resting-state connectivity biomarkers define neurophysiological subtypes of depression. Nature Medicine, 2016 December 5.

•  Neuroimaging categorizes for depression subtypes. Weill Cornell Medicine press release, Dec. 5, 2016.

DR. THOMAS W. MILLER, PH.D, ABPP

Thomas W. Miller, Ph.D., ABPP, is a professor emeritus and senior research scientist, Center for Health, Intervention and Prevention, University of Connecticut; retired service chief from the VA Medical Center; and tenured professor in the Department of Psychiatry, College of Medicine, University of Kentucky.

more articles by Dr thomas w. miller