BATTLING BALDNESS

Some men look in the mirror and regard a receding hairline with distress, wondering if there is a cure for baldness. Currently, the only truly effective medically proven way to arrest hair loss is to lower dihydrotestosterone (DHT) levels. DHT is a form of testosterone that regulates beard growth and hair loss. Higher levels of DHT produce fuller beards at the cost of male pattern baldness. Lower levels of DHT ensure a full head of hair at the cost of the inability to grow a beard.

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HACKING THE HUMAN BRAIN

Many people enjoy visiting various Web sites and apps that challenge the brain by luring them deeper and deeper into cyber space. Cyber addiction comes in several forms, but all impact the brain. The past two decades have acquainted many people with the concept of hacking. It is why people strive to protect their computers and smartphones from outside sources trying to break in to steal information, implant malware and preocupy their lives.

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HEART ATTACK AND MEN

According to the American Heart Association (AHA), more than one in three adult men has heart disease. Men around the age of 55 years are more likely than women to experience a heart attack.  Men often ignore the symptoms of a heart attack because they are uncertain about what they are feeling and don’t want to be embarrassed by a simple diagnosis, such as heartburn. According to the Centers for Disease Control and Prevention (CDC), 50 percent of men who die from coronary heart disease....

….FULL ARTICLE

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and this will regenerate hair follicles and improve hair growth. One study showed SM04554 was safe for use with very few side effects. A second study’s results look promising: Follicle counts increased even after treatment had ceased after 90 days. A third, larger-scale study performed with more than 300 male subjects found hair count and density increased.


An autoimmune disease called alopecia areata causes complete hair loss, including the eyebrows and eyelashes. In a study conducted at Stanford, Yale and Columbia universities, 66 alopecia areata patients received the rheumatoid arthritis pill Xeljanz. More than half the subjects saw hair regrowth. A third recovered more than 50 percent of their hair loss. In another study, nine of 12 patients with alopecia areata recovered more than 50 percent of hair growth using a similar drug, Jakarfi, which is approved for cancer treatment. Medical researchers are evenly split about whether a topical ointment from either of these drugs may be useful for male pattern baldness.


The carrot on a stick many men are waiting for is multiplication via cloning. It is said to be five years away. The idea is to take hair unaffected by DHT from the back of the head and miniaturize and clone it to make hundreds or thousands of similar hairs. Although there has been success with this procedure in experiments, it remains too costly and impractical for the market.

Some men look in the mirror and regard a receding hairline with distress, wondering if there is a cure for baldness. Currently, the only truly effective medically proven way to arrest hair loss is to lower dihydrotestosterone (DHT) levels. DHT is a form of testosterone that regulates beard growth and hair loss. Higher levels of DHT produce fuller beards at the cost of male pattern baldness. Lower levels of DHT ensure a full head of hair at the cost of the inability to grow a beard. Two treatments clinically proven to be successful for male pattern baldness are finasteride and minoxidil.


Finasteride, the generic name for Proscar and Propecia, works by inhibiting the enzyme that converts testosterone into DHT. A 1-mg dose of finasteride taken daily can lower DHT levels by as much as 60 percent. This decrease has proven to stop the progression of hair loss in 86 percent of men taking the drug during clinical trials, and 65 percent of trial participants experienced a substantial increase in hair growth. However, finasteride doesn’t work for everyone. Its biggest downside is its side effects, which include impotence, swelling of hands or feet, dizziness, headache, runny nose and skin rash.


Minoxidil (Ionitne) was the first drug approved by the FDA for the treatment of male pattern baldness. Originally used to treat high blood pressure, minoxidil caused hair growth in unexpected places, such as the cheeks and forehead. Topically applying minoxidil to

BATTLING BALDNESS

ANGELA S. HOOVER

Angela is a staff writer for Health & Wellness magazine.

more articles by Angela s. hoover

balding areas has been clinically proven to slow the progression of hair loss and regrow some hair. But most experts see it as a marginally effective drug because it does not affect the hormonal process of hair loss. Its positive effects are often temporary.


U.S. scientists exploring how certain cancer tumors form stumbled upon cells that make hair turn gray. The protein KROX20, commonly associated with nerve development, is also progenitor or precursor cells that become the hair shaft. These cells then produce another protein called stem cell factor that is essential for hair pigmentation. The results were published in the journal Genes & Development.


A new drug, SM04554, is in the beginning phases of testing. Instead of blocking DHT as finasteride does, SM04554 enables the Wnt pathway, which is known to cause hair growth. In addition to generating new hair follicles, the Wnt pathway is also believed to initiate and maintain the active phase of hair growth. The natural process of the Wnt pathway can be blocked by a protein called DKK1. Researchers theorize SM04554 can inhibit DKK1 from stopping the Wnt pathway,